|
rs6504649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of the other investigated XYLT-I and XYLT-II variations (XYLT-I: c.1989T>C in exon 9; XYLT-II: IVS6-9T>C and IVS6-14_IVS6-13insG in intron 5; and c.2402C>G: p.T801R in exon 11) were not different between patients with and without diabetic nephropathy.
|
17003309 |
2006 |
|
rs61758388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The XYLT-I c.343G>T polymorphism contributes to the genetic susceptibility to development of diabetic nephropathy in type 1 diabetic patients.
|
17003309 |
2006 |
|
rs12708815
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allelic frequencies of the other investigated XYLT-I and XYLT-II variations (XYLT-I: c.1989T>C in exon 9; XYLT-II: IVS6-9T>C and IVS6-14_IVS6-13insG in intron 5; and c.2402C>G: p.T801R in exon 11) were not different between patients with and without diabetic nephropathy.
|
17003309 |
2006 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant difference was observed in the genotype and allele distribution of eNOS -786T > C, intron 4a4b, p22phox 242C > T and XRCC1 Arg399Gln polymorphisms between T2DM groups with and without DN.
|
25041504 |
2014 |
|
rs140407862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunofluorescence staining of COL4<i>α</i>3 was performed in kidney specimens of patients with DKD with or without R408H and M1209I of <i>COL4A3</i> variants.
|
30012629 |
2018 |
|
rs2120243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with the GG variant of rs2305619 showed 4.078-fold higher susceptibility to DN than those with the AA variant (OR=4.078, 95% CI=1.370-12.135, p=0.012); patients with the AA variant of rs2120243 had a lower risk of developing DN (OR=0.213, 95% CI=0.055-0.826, p=0.025).
|
28119515 |
2017 |
|
rs833061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Most of these eleven genetic variants were involved in GPCR signaling and receptor binding pathways whereas four were involved in chronic kidney failure. rs833061 [OR 2.08 (95% CI 1.63-2.66)] in the VEGFA gene and rs3917887 [OR 2.04 (95% CI 1.64-2.54)] in the CCL2 gene showed the most significant association with the risk of diabetic nephropathy.
|
25280384 |
2014 |
|
rs2281999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD group and control group of patients with T2DM.
|
31713534 |
2019 |
|
rs4293393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of UMOD rs4293393 variant with C allele was significantly higher in individuals with DN.
|
29578190 |
2017 |
|
rs4293393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 646 individuals, 208 with T2DM without evidence of kidney disease (DM), 221 with DN and 217 healthy controls (HC) were genotyped for UMOD variant rs4293393T>C by restriction fragment length polymorphism.
|
29578190 |
2017 |
|
rs660339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated whether UCP2 -866G/A, Ala55Val and Ins/Del polymorphisms were associated with DKD in patients with type 2 diabetes mellitus (T2DM), and whether they had an effect on UCP2 gene expression in human kidney tissue biopsies.
|
26218518 |
2015 |
|
rs7638459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the six SNPs, only rs7638459 was suspected as risk factor of T2D without DN, fitting the log-additive model.
|
23544998 |
2013 |
|
rs953239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs953239 was found to be a protective factor of getting DN in T2D, also fitting the log-additive model.
|
23544998 |
2013 |
|
rs2295490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine whether the Q84R polymorphism (rs2295490), alone or in combination with smoking, contributes to the development of diabetic nephropathy, a case-control study was performed in 812 Chinese patients with type 2 diabetes.
|
25447894 |
2015 |
|
rs16928973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significant association was also found between rs16928973 in TRAF6 gene and diabetic nephropathy (DN) under the allelic model.
|
27062898 |
2016 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study was designed to investigate the association of TNF-α [-308G/A, (rs1800629)] single nucleotide polymorphism (SNP) on the susceptibility to DN subjects and to correlate it with the plasma levels of TNF-α along with circulatory TNF-α receptor super family cytokines (sTNFR-1 and sTNFR-2).
|
29042282 |
2018 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In type 2 diabetic patients, however, heterozygote carriers of the Asp299Gly and Thr399Ile genotypes had a significantly reduced prevalence of diabetic neuropathy (odds ratio 0.35 [95% CI 0.19-0.61]; P = 0.0002); no association with diabetic nephropathy was found.
|
14693986 |
2004 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In type 2 diabetic patients, however, heterozygote carriers of the Asp299Gly and Thr399Ile genotypes had a significantly reduced prevalence of diabetic neuropathy (odds ratio 0.35 [95% CI 0.19-0.61]; P = 0.0002); no association with diabetic nephropathy was found.
|
14693986 |
2004 |
|
rs5030717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia.
|
30211669 |
2018 |
|
rs5030718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia.
|
30211669 |
2018 |
|
rs11130362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found combined effect of TKT SNP rs11130362 and FN3K SNP rs1056534 on DN progression (p<0.01).
|
23492569 |
2014 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TGF-beta1 T29C polymorphism is not associated with the progression of diabetic nephropathy.
|
11576951 |
2001 |
|
rs7903146
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The strong LD existed between the 2 single nucleotide polymorphisms and haplotype T-T (rs7903146-rs290487) increased the susceptibility to DN (OR = 2.63, 95% CI = 1.31-5.25).TCF7L2 rs7903146 polymorphism may be associated with the susceptibility to DN in Chinese Han population, but rs290487 is not.
|
30290587 |
2018 |
|
rs7903146
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
|
rs7903146
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our study the T allele of the rs7903146 SNP in the TCF7L2 gene confers the risk of developing diabetic nephropathy.
|
24574000 |
2014 |